Estimating the Functional Capabilities of Sarcoplasmic Reticulum in Cardiac Muscle
نویسندگان
چکیده
منابع مشابه
The control of sarcoplasmic reticulum Ca content in cardiac muscle.
Most of the calcium that activates contraction in the heart comes from the sarcoplasmic reticulum (SR) and it is therefore essential to control the SR Ca content. SR Ca content reflects the balance between uptake (via the SR Ca-ATPase, SERCA) and release, largely via the ryanodine receptor (RyR). Unwanted changes of SR Ca are prevented because, for example, an increase of SR Ca content increase...
متن کاملThe sarcoplasmic reticulum of skeletal and cardiac muscle.
This paper traces the development of our present concept of the structural organization of the sareoplasmic reticulum in striated muscle and reviews the physiologic evidence for its participation in intracellular impulse conduction. Comparative observations are presented showing that this system of membrane-limited tubules is particularly well developed in exceptionally fast-acting skeletal mus...
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The ryanodine receptor (RYR)/Ca2+ release channel of avian cardiac muscle was localized by immunocytochemical techniques and biochemically characterized using isolated membrane and receptor protein fractions. Monoclonal antibody C3-33 raised against the canine cardiac RYR bound to the junctional sarcoplasmic reticulum of pigeon and finch hearts, both at peripheral couplings and at extended junc...
متن کاملThe sarcoplasmic reticulum of smooth muscle fibers.
The ability of the sarcoplasmic (endoplasmic) reticulum (SR, ER) of smooth muscle cells to accumulate Ca was demonstrated by measuring the uptake of 45Ca in fibers which were chemically skinned with saponin, and by electron cytochemistry of the accumulated Ca. The Ca uptake was dependent on ATP and it was stimulated by oxalate, as it is the case in SR of striated muscle. Electron microscopy of ...
متن کاملThe Sarcoplasmic Reticulum of Striped Muscle
Dr. Edwards and colleagues have demonstrated that many types of vertebrate and invertebrate muscle possess an extensive representation of the endoplasmic reticulum, and have observed that this may be arranged in longitudinal members running parallel to the myofibrils, and in transverse membranes, often located at the level of the junctions of A and I bands. Dr. Porter has called attention to so...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1974
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.34.4.531